Molecular epidemiology; New but impressive

An Impressive Structure Ex Vivo but Not in Culture

Potter and Damiano recently assessed the hydrodynamic dimensions of the endothelial glycocalyx in vivo (mouse cremaster muscle venules) and in vitro (human umbilical vein and bovine aorta endothelium cultured in perfused microchannels) using fluorescent microparticle image velocimetry (Circ Res. 2008;102:770–776). Great discrepancy was observed, the glycocalyx presenting a zone of interaction e...

Molecular Epidemiology of Human Papillomavirus in Pterygium

Abstract Background and Objective: Ophthalmic pterygium is a potentially vision-threatening lesion of unknown etiology that often extends on the corneal surface and has a worldwide distribution. Despite various studies, the pathogenesis of pterygium remains unclear and the involvement of human papillomavirus is controversial. We aimed to investigate the involvement of papillomavirus in pte...

Molecular medicine and clinical epidemiology: new era, new choices.

What areas should new researchers in developing countries choose in order to give relevant contributions to medical knowledge? Obviously the answer involves many different subjects. It seems to us that presently molecular medicine is very attractive. On the other hand, the applications of discoveries in molecular medicine and new therapeutic approaches require good clinical investigation method...

Molecular Genetics and Epidemiology of Vitiligo

Background: Vitiligo is an acquired, idiopathic, and common depigmentation disorder of the skin that affects people of all ages and both sexes equally in the worldwide. Although etiology of the disease is unknown, there are theories such as environment and genetic factors. Methods: In this article, we collected and summarized the appropriate manuscripts regarding the epidemiology and gene...

Molecular Epidemiology of Eastern Equine Encephalitis Virus, New York

Perpetuation, overwintering, and extinction of eastern equine encephalitis virus (EEEV) in northern foci are poorly understood. We therefore sought to describe the molecular epidemiology of EEEV in New York State during current and past epizootics. To determine whether EEEV overwinters, is periodically reintroduced, or both, we sequenced the E2 and partial NSP3 coding regions of 42 EEEV isolate...

An impressive ceiling.